एक महीनेपश्चात, एमएचआरए के वैज्ञानि क मूल्यांकनकर्ता एलि सन बैनर सि म्पसन नेईमेल के माध्यम सेजवाबदि या: “हमनेअपनेरि कॉर्ड खोजेऔर सभी प्रासंगि क ईमेल संलग्न कि ए हैं।“ लेकि न उन्होंनेयह भी नोट कि या: “दुनि या भर मेंअन्य नि यमों के अनुरूप एमएचआरए का मानना हैकि गुणवत्ता, सुरक्षा और प्रभावकारि ता परवर्तमान मेंउपलब्ध आंकड़ों के आधार पर फि नास्टेराइड के लाभों और जोखि मों का संतुलन सकारात्मक है।“
(एमएचआरए की पूरी प्रति क्रि या के लि ए, जि से२९ दि संबर को सार्वजनि क कि या गया, यहांक्लि क करें।)कुंठाग्रस्त, २९ सि तंबर को, रयान नेफि र एजेंसी को लि खा, उन्हेंयह बतानेके लि ए कि कैसेफि नास्टेराइड नेउनकेस्वास्थ्य, जीवि का और परि वार को नष्ट कर दि या था। दो महीनेबाद उन्हेंसि म्पसन सेएक प्रति क्रि या मि ली, भागों मेंउल्लेख:
जैसा कि मुझेयकीन हैकि आप जागरूक [हैं], प्रोपेशि या सेदुष्प्रभाव पर अमेरि का और यूरोप मेंअलग अलगलेबलि ंग है, जैसेकि यौन रोग … कुछ रोगों मेंउपचार बंद करनेके बाद जारी रहनेके लि ए जाना जाता हैऔर यहयूके और ईयूमेंउत्पाद सूची मेंवर्णि त है … इसके अति रि क्त, अवसादि त मनोदशा, चि ंता, अवसाद और, अनि त्य,आत्मघाती वि चारों को फि नास्टेराइड १ मि लीग्राम उपचार के दुष्प्रभाव के रूप मेंजाना जाता है…..
‘पीएफएस’ का वैज्ञानि क समुदाय या चि कि त्सकीय रूप सेमान्यता प्राप्त सि ंड्रोम के रूप मेंव्यापक रूप सेमान्यताप्राप्त नहीं है। जैसेकि , ‘पीएफएस’ फि नास्टेराइड के साथ उपचार का एक ज्ञात दुष्प्रभाव नहीं है। हालांकि , कईव्यक्ति गत लक्षण जि न्हेंमरीज़ ‘पीएफएस’ सेसंबंधि त मानतेहैं, उत्पाद सूची मेंवर्णि त हैं… वर्तमान लेबलि ंग कोदेखतेहुए, कोई नया सबूत नहीं हैजो वर्तमान मेंउत्पादन सूचना के लि ए और अपडेट की गारंटी देगा।
(सि म्पसन की पूरी प्रति क्रि या के लि ए, यहांक्लि क करें।)
Frustrated, Ryan again wrote the agency, on Sept. 29, to tell them how finasteride had decimated his health, career and family. Two months later he received a response from Simpson, reading in part:
As I am sure you [are] aware, the labelling on the side effects with Propecia are different in the US and in Europe, such that sexual dysfunction…is known to persist after discontinuation of treatment in some patients and this is described in the product information in the UK and EU… Additionally, depressed mood, anxiety, depression and, less frequently, suicidal thoughts are known side-effects of treatment with finasteride 1 mg…
‘PFS’ is not widely recognised by the scientific community or as a medically recognised syndrome. As such, ‘PFS’ is not a known side effect of treatment with finasteride. However, many of the individual symptoms which patients consider are associated with ‘PFS’ are described in the product information… Given the current labelling, there is no new evidence which would warrant any further updates to the product information at present.
(For Simpson’s full response, click here.)
Again disheartened that the MHRA declined to mandate more thorough and strenuous finasteride warnings, let alone educate doctors and fund PFS research, Ryan thought he’d hit a brick wall. But less than a month later he learned it had heeded one of his complaints—that Sons, an online pharmacy touting itself as “Next generation men’s health and well-being,” completely glossed over the drug’s potential to cause psychological and cognitive damage in a subset of patients.
On Dec. 14, based on evidence submitted by Ryan, the agency published a decision titled September 2021 Promotion of finasteride by Careforsons Limited t/a Sons. It read, in part:
A member of the public contacted MHRA to raise concerns about the information provided for finasteride on the Sons website. The complainant did not consider that the mental-health side-effects and emotional wellbeing were sufficiently or appropriately discussed on the webpages where this prescription-only medicine was highlighted.
MHRA contacted Careforsons Limited regarding the concerns and asked them to review their website to ensure readers are given a balanced overview of the potential risks and benefits of using this medicine and to avoid absolute statements of safety.
Among the statements Sons makes on its Finasteride FAQs page are:
- “Finasteride is safe… most men take the medication daily for years without any issues at all.”
- “Finasteride doesn’t stay in your system for very long once you stop taking it… In fact, on stopping the medication it is usually completely excreted after seven days.”
- “For those people that do experience mild side effects, improvement usually follows after a short while. If they do not, however, we would suggest stopping the medication—thankfully side effects tend only to occur in the first six months of usage and in the vast majority of people resolve on stopping the medication.”
“I realize this is a small gesture by the MHRA, but it’s significant to me—as it should be to all PFS patients—because it shows that a single voice can help hold an entire system accountable for protecting public health,” Ryan tells us.
“I encourage anyone who believes that nothing can be done about the PFS epidemic to begin educating him- or herself immediately on the mechanisms in place at their own drug agencies for bringing the horrors of PFS to light.”
Few men know those horrors better than Ryan. Then an operations manager overseeing more than 100 staffers in the Civil Service, a branch of Her Majesty’s Revenue and Customs division that implements national policies, he was first prescribed Propecia in 1998.
“The only advertised side effect of Propecia was the potential for a temporary loss of libido which, it was claimed, would return upon quitting the drug,” says Ryan. “Yet my experience was vastly different. Within weeks, I developed extreme anxiety and chronic insomnia.”
So Ryan, who’d enjoyed tiptop levels of fitness his whole life and had zero history of such conditions, returned to the prescribing GP, only to be told that the cause was stress.
Over the next several years, he says he developed an array of more than 30 additional symptoms that seems cribbed from a Stephen King tale, including these 14 most severe:
- adrenal dysfunction
- autonomic dysfunction
- androgen deprivation
- benign tumors
- chronic insomnia
- cognitive dysfunction
- dermatological disorders
- gastrointestinal disorders
- generalized anxiety disorder
- global soft tissue atrophy
- muscle atrophy
- neuropathy
- suicidal ideation
- sexual dysfunction
(To access the PFS Foundation’s Reported PFS Symptoms page, click here.)
In all, Ryan spent 15 years without any hint that finasteride could be the cause of his suffering. Worse, he says, is that, among the multitude of MDs who treated him, no one inquired about his finasteride use.
During his own search for what ailed him, Ryan learned of the Yellow Card Scheme, the MHRA’s system for “collecting and monitoring information on safety concerns such as suspected side effects or adverse incidents involving medicines and medical devices.”
“It’s extremely worrying that not one doctor suggested I submit a Yellow Card on finasteride or filed one on my behalf,” he says.
Only after stumbling upon the PFS Foundation website in 2015 did he flush his Propecia down the toilet, never to look back. A year after that he was officially diagnosed with PFS by an endocrinologist.
Still, Ryan’s life failed to improve. In fact, things have gotten progressively worse. PFS has taken an enormous toll on his marriage and personal relationships. He and wife Lyndsey have a nine-year-old son, and that family is the main reason he continues to fight.
“I have a lot to live for but my unrelenting symptoms make each day unbearable,” he says. “And the fact that virtually every doctor I’ve seen has no clue as to what’s going on makes my situation even worse. If things don’t change soon, more lives will be lost.”
Because of the deterioration in his physical health and cognitive function, Ryan finally left his job in 2019. “According to my most recent medical assessment, it’s unlikely I’ll ever be able to work again,” he says.
“I’m apparently unique in that I’m one of the unlucky few who gets worse—and is still alive—after taking this Frankenstein of a drug.”
If you’d like to learn more about navigating pharmacovigilance channels and/or help with his efforts, feel free to contact Ryan at clarkpod1@hotmail.co.uk.
Anyone living in the US who suffers from PFS should report his symptoms to the US Food and Drug Administration. Anyone living outside the US who suffers from PFS should report his/her symptoms to the US Food and Drug Administration and to his/her national drug-regulatory agency, as directed on our Report Your Side Effects page.
Finally, if you or a loved one are suffering from PFS, and feeling depressed or unstable, please don’t hesitate to contact the PFS Foundation as soon as possible via our Patient Support hotline: social@pfsfoundation.org
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