PFS patients also showed lowered allopregnanolone [a neurosteriod] that plays a prominent role both sexual function and also regulation of mood… Finasteride and dutasteride increases the upregulation of androgen receptors. And there may be some genetic polymorphisms that may be linked to the risk. Which means that in some individuals, there may be a genetic predisposition toward the development of PFS. In PFS patients, there are 1,446 genes that are over-expressed, and 2,318 genes that are under-expressed.
—Post-SSRI Sexual Dysfunction and PFS : Exploring the Overlaps and Potential Treatments: Psychiatry Simplified, July 3, 2024