Concern regarding adverse effects of finasteride is increasing. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS).… Out of 79 participants…the most frequent sexual symptoms referred were a loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). The most frequent non-sexual symptoms have reduced the feeling of life pleasure or emotions (anhedonia) (75.9%), lack of mental concentration (72.2%), and loss of muscle tone/mass (51.9%).…Further studies are necessary to investigate the pathophysiological and biochemical pathways leading to the post-finasteride syndrome.
Chiriacò G, Cauci S, Mazzon G, Trombetta C, et al. An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. Andrology. 2016 Mar;4(2):245-50. doi: 10.1111/andr.12147. Epub 2016 Jan 13. [PubMed]